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有效利用扩展标准供者(ECD)已故供者肾脏库:标签效应分析。

Efficient utilization of the expanded criteria donor (ECD) deceased donor kidney pool: an analysis of the effect of labeling.

机构信息

Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA.

出版信息

Am J Transplant. 2010 Feb;10(2):304-9. doi: 10.1111/j.1600-6143.2009.02937.x. Epub 2010 Jan 6.

Abstract

We investigated the effect of the expanded criteria donor (ECD) label on (i) recovery of kidneys and (ii) acceptance for transplantation given recovery. An ECD is age > or = 60, or age 50-59 with > or = 2 of 3 specified comorbidities. Using data from the Scientific Registry of Transplant Recipients from 1999 to 2005, we modeled recovery rates through linear regression and transplantation probabilities via logistic regression, focusing on organs from donors just-younger versus just-older than the ECD age thresholds. We split the sample at July 1, 2002 to determine how decisions changed at the approximate time of implementation of the ECD definition. Before July 2002, the number of recovered kidneys with 0-1 comorbidities dropped at age 60, but transplantation probabilities given recovery did not. After July 2002, the number of recovered kidneys with 0-1 comorbidities rose at age 60, but transplantation probabilities contingent on recovery declined. No similar trends were observed at donor age 50 among donors with > or = 2 comorbidities. Overall, implementation of the ECD definition coincided with a reversal of an apparent reluctance to recover kidneys from donors over age 59, but increased selectiveness on the part of surgeons/centers with respect to these kidneys.

摘要

我们研究了扩展标准供者(ECD)标签对(i)肾脏恢复和(ii)恢复后接受移植的影响。ECD 是指年龄大于或等于 60 岁,或年龄在 50-59 岁且有 3 种指定合并症中的 2 种以上。利用 1999 年至 2005 年的移植受者科学登记处的数据,我们通过线性回归模型对恢复率进行建模,并通过逻辑回归模型对移植概率进行建模,重点关注刚好比 ECD 年龄阈值年轻和刚好比 ECD 年龄阈值年长的供者的器官。我们在 2002 年 7 月 1 日将样本分开,以确定 ECD 定义实施前后决策的变化。在 2002 年 7 月之前,年龄为 60 岁时,有 0-1 种合并症的恢复肾脏数量下降,但恢复后移植的可能性没有下降。2002 年 7 月之后,年龄为 60 岁时,有 0-1 种合并症的恢复肾脏数量上升,但恢复后移植的可能性下降。在有 2 种以上合并症的供者中,50 岁的供者中没有观察到类似的趋势。总体而言,ECD 定义的实施恰逢对 59 岁以上供者的肾脏恢复的明显不情愿的逆转,但外科医生/中心对这些肾脏的选择性增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4456011/46b8465870f0/nihms694137f1.jpg

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Centers for Disease Control 'high-risk' donors and kidney utilization.疾病预防控制中心“高危”供者与肾脏利用。
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本文引用的文献

1
It is time to re-think 'extended criteria'.是时候重新思考“扩展标准”了。
Am J Transplant. 2006 Oct;6(10):2225-7. doi: 10.1111/j.1600-6143.2006.01506.x. Epub 2006 Aug 21.
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Public education and organ donation.公众教育与器官捐赠。
Transplant Proc. 1997 Feb-Mar;29(1-2):1614-7. doi: 10.1016/s0041-1345(97)82536-5.

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