René Rachou Institute, Laboratory of Cellular and Molecular Immunology, Belo Horizonte, MG, Brazil.
Clin Exp Dermatol. 2009 Dec;34(8):e709-11. doi: 10.1111/j.1365-2230.2009.03440.x. Epub 2009 Jul 3.
Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed.
急性泛发性发疹性脓疱病（AGEP）是一种不常见的疾病，表现为非滤泡性红斑性无菌脓疱疹。超过 90%的病例是由药物不良反应引起的，通常由抗感染全身药物引发。我们报告了一例伊曲康唑诱导的 AGEP 病例，对其细胞因子/趋化因子产生和药物特异性细胞反应性进行了评估。我们发现，AGEP 与其他 T 细胞介导的药物疹一样，改变了患者的免疫状态，可能有利于 T 细胞的激活、募集和调节。文献中描述了少数几例伊曲康唑诱导的 AGEP 病例，据我们所知，这是首例评估其细胞免疫学特征的报告。
