Di Lernia Vito, Ricci Cinzia
Department of Internal Medicine and Medical Specialities, Dermatology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
Indian J Dermatol. 2015 Mar-Apr;60(2):212. doi: 10.4103/0019-5154.152572.
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is usually caused by drugs. It is characterized by fever and acute, extensive occurrence of disseminated sterile pustules, accompanied by fever, malaise and peripheral blood leucocytosis. There have been several reports to date of AGEP following exposure to antifungals. In particular, terbinafine is included in the list of the agents conferring the highest risk of AGEP. The authors report the case of a 70-year-old male patient who developed AGEP shortly after commencing treatment with fluconazole, which has been reported in association with AGEP in a single case report. To our knowledge, this is the first reported case of AGEP associated with positive fluconazole patch test.
急性泛发性脓疱性皮病（AGEP）是一种严重的皮肤不良反应，通常由药物引起。其特征为发热以及急性、广泛出现的播散性无菌脓疱，伴有发热、不适和外周血白细胞增多。迄今为止，已有数例接触抗真菌药后发生AGEP的报道。特别是，特比萘芬被列入发生AGEP风险最高的药物清单中。作者报告了一例70岁男性患者，该患者在开始使用氟康唑治疗后不久即发生AGEP，此前曾有一份个案报告报道过氟康唑与AGEP有关。据我们所知，这是首例与氟康唑斑贴试验阳性相关的AGEP报道病例。
