Institute of Pathological Physiology, Faculty of Medicine, Charles University, Hradec Kralove, Prague, Czech Republic.
Clin Exp Dermatol. 2009 Dec;34(8):e881-3. doi: 10.1111/j.1365-2230.2009.03648.x.
The Goeckerman regimen (GR) is one of the oldest effective treatments for psoriasis. It involves daily dermal application of crude coal tar with dermal exposure to ultraviolet (UV) radiation. A study was carried out to evaluate the genotoxic risk of GR by comparing p53 protein plasma level and chromosomal aberrations (CA) in peripheral lymphocytes in 33 patients with psoriasis, before and after GR. Psoriasis Area and Severity Index (PASI) was used to evaluate the efficacy of GR. PASI significantly decreased after GR (P < 0.001), confirming the excellent efficacy of the treatment, However, significant increases in level of p53 protein (P < 0.05) and CA (P < 0.001) after treatment indicates that this method carries an increased genotoxic risk in patients with psoriasis.
煤焦油光疗（GR）是治疗银屑病最古老、最有效的方法之一。它包括每天在皮肤上涂抹粗制煤焦油，并进行紫外线（UV）辐射。为了评估 GR 的遗传毒性风险，研究比较了 33 例银屑病患者在 GR 前后血浆 p53 蛋白水平和外周血淋巴细胞染色体畸变（CA），并进行了这项研究。银屑病面积和严重程度指数（PASI）用于评估 GR 的疗效。GR 后 PASI 显著降低（P < 0.001），证实了该治疗方法的卓越疗效，但治疗后 p53 蛋白水平（P < 0.05）和 CA（P < 0.001）显著增加表明，这种方法会增加银屑病患者的遗传毒性风险。
