Shah P C, Rao K R, Patel A R
Br J Dermatol. 1978 Jun;98(6):675-80. doi: 10.1111/j.1365-2133.1978.tb03587.x.
Cyclophosphamide therapy may occasionally cuase black pigmentation of the nails. We report five cases with this side effect and review the data on eleven cases in the literature. These changes start in the proximal nail beds and progress distally; on withdrawal of cyclophosphamide, clearing of the nail pigmentation proceeds in a similar fashion. The development of the nail pigmentation does not bear any relation to the primary condition for which cyclophosphamide was prescribed. The dose of the drug before the onset of pigmentation ranged from 1.2 to 12.3 g; the duration of treatment ranged from 10 days to 26 weeks. The mechanism of the nail pigmentation is unknown.
环磷酰胺治疗偶尔可能导致指甲黑色素沉着。我们报告了5例出现这种副作用的病例，并回顾了文献中11例病例的数据。这些变化始于近端甲床，并向远端发展；停用环磷酰胺后，指甲色素沉着的消退也以类似方式进行。指甲色素沉着的发生与使用环磷酰胺治疗的原发疾病无关。色素沉着出现前药物剂量为1.2至12.3克；治疗持续时间为10天至26周。指甲色素沉着的机制尚不清楚。
