缓解期类风湿关节炎患者的前足疾病活动：一项队列研究的结果。
Forefoot disease activity in rheumatoid arthritis patients in remission: results of a cohort study.
机构信息
Department of Rehabilitation Medicine and Psychology, Jan van Breemen Institute, Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands.
出版信息
Arthritis Res Ther. 2010;12(1):R3. doi: 10.1186/ar2901. Epub 2010 Jan 7.
INTRODUCTION
The aim of our study was to investigate the presence of disease activity in the metatarsophalangeal (MTP) joints of the forefoot in rheumatoid arthritis (RA) patients in remission according to the Disease Activity Score based on 28 joints (DAS28) remission criterion.
METHODS
A total of 848 patients with recent-onset RA were included from 1995 through 2007. The DAS28 and pain and swelling of the MTP joints were assessed annually. The data were analyzed using descriptive techniques.
RESULTS
On average, 35% of the patients fulfilled the remission criterion of DAS28 <2.6 during the first eight years of RA. On average, 29% of these patients had at least one painful MTP joint and, on average, 31% had at least one swollen MTP joint during follow-up. Forty percent, on average, had at least one involved MTP joint (pain and/or swelling).
CONCLUSIONS
Painful and/or swollen MTP joints were detected in a substantial proportion of patients classified as being in remission. Therefore, examination of the foot joints - irrespective of the patient's state of remission - seems indicated in order to provide optimal foot care.
简介
我们的研究目的是根据 28 个关节疾病活动评分（DAS28）缓解标准，调查处于缓解期的类风湿关节炎（RA）患者前足跖趾（MTP）关节是否存在疾病活动。
方法
共纳入 1995 年至 2007 年间发病的 848 例新发 RA 患者。每年评估 DAS28 和 MTP 关节的疼痛和肿胀。采用描述性技术对数据进行分析。
结果
在 RA 的前 8 年中，平均有 35%的患者符合 DAS28<2.6 的缓解标准。平均而言，这些患者中有 29%至少有一个疼痛的 MTP 关节，平均有 31%至少有一个肿胀的 MTP 关节在随访期间。平均而言，40%的患者至少有一个受累的 MTP 关节（疼痛和/或肿胀）。
结论
在被归类为缓解的患者中，仍有相当一部分患者存在疼痛和/或肿胀的 MTP 关节。因此，即使患者处于缓解期，似乎也需要检查足部关节，以提供最佳的足部护理。
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