Department of Microbiology & Infectious Diseases, Uludağ University, Bursa, Turkey.
Epidemiol Infect. 2010 Sep;138(9):1328-35. doi: 10.1017/S0950268809991531. Epub 2010 Jan 8.
The incidence of nosocomial candidaemia was evaluated in a retrospective study in a Turkish tertiary-care hospital. Over a 12-year period (1996-2007), a total of 743 episodes of candidaemia occurred in 743 patients, accounting for an average incidence of 1.9 episodes/1000 admissions and 2.9 episodes/10 000 patient-days per year. The annual incidence was almost constant during the study period except for 1996 when it was significantly higher in comparison with other years (P<0.05). The most common species isolated was Candida albicans (45%), followed by C. parapsilosis (26%), C. tropicalis (7%), C. krusei (7%), and C. glabrata (3.5%). A significant increase in C. albicans isolates causing candidaemia linked to a decrease in C. parapsilosis isolates in adult patients and C. krusei isolates in children was found between the two 6-year study periods. This trend reflects improved infection control at Uludağ University Hospital. Ninety percent of isolates were susceptible to fluconazole (8 microg/ml) and resistance was found only in C. glabrata and C. parapsilosis isolates. Regular local surveillance of Candida spp. is important in order to develop empirical treatment protocols to reduce the incidence and mortality of candidaemia.
本研究对土耳其一家三级医院的院内念珠菌血症发病率进行了回顾性评估。在 12 年期间（1996-2007 年），743 例念珠菌血症患者共发生 743 例次，平均发病率为 1.9 例/1000 例次，2.9 例/10000 例患者天。除 1996 年外，研究期间的年发病率几乎保持不变，而 1996 年的发病率明显高于其他年份（P<0.05）。最常见的分离菌是白色念珠菌（45%），其次是近平滑念珠菌（26%）、热带念珠菌（7%）、克柔念珠菌（7%）和光滑念珠菌（3.5%）。在两个 6 年研究期间，成人患者中导致念珠菌血症的白色念珠菌分离株的显著增加与近平滑念珠菌分离株的减少以及儿童中克柔念珠菌分离株的减少相关，这反映出乌尔法大学医院感染控制的改善。90%的分离株对氟康唑（8 μg/ml）敏感，仅在光滑念珠菌和近平滑念珠菌分离株中发现耐药性。为了制定经验性治疗方案以降低念珠菌血症的发病率和死亡率，定期对念珠菌进行局部监测非常重要。
