Jensen Søren Astrup, Baeksgaard Lene, Petersen Lone Nørgaard, Reiter Lars, Sørensen Jens Benn
Onkologisk Afdeling 5073, Rigshospitalet, DK-2100 København Ø, Denmark.
Ugeskr Laeger. 2010 Jan 4;172(1):48-51.
5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
5-氟尿嘧啶和卡培他滨对多种实体瘤具有显著的抗肿瘤活性。导致心绞痛、心律失常和梗死的心脏毒性是与这些药物相关的严重不良事件。本文讨论了其发病机制，描述了心脏毒性的症状、硝酸甘油干预措施以及作为心脏合并症的危险因素。发生心脏毒性后，由于缺乏替代的活性药物，可能有理由再次使用5-氟尿嘧啶。在这种情况下，在医学抗心绞痛预防支持下的剂量调整后的基于5-氟尿嘧啶的化疗是可行的。
