Tunio Mutahar Ali, Hashmi Altaf, Shoaib Muhammad
Sindh Institute of Urology & Transplantation, Karachi, Pakistan.
Pak J Pharm Sci. 2012 Jan;25(1):277-81.
Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) which is converted in tumor cells to 5-FU by the enzyme thymidine phosphorylase. Nowadays, it is being widely used into the management of colorectal, breast and head and neck cancers because of its oral route and its comparable efficacy with 5-FU. 5-FU induced cardiotoxicity (angina and myocardial infarction) has been reported the literature, but capecitabine induced cardiotoxicity is less reported event. We report a patient with diagnosis of locally advanced adenocarcinoma of rectum who developed symptomatic bradycardia and acute ischemia while receiving oral capecitabine 825mg/m(2) twice daily with preoperative radiation.
卡培他滨是5-氟尿嘧啶（5-FU）的口服前体药物，它在肿瘤细胞中通过胸苷磷酸化酶转化为5-FU。如今，由于其口服给药途径以及与5-FU相当的疗效，它被广泛用于结直肠癌、乳腺癌和头颈癌的治疗。文献中已报道5-FU可诱发心脏毒性（心绞痛和心肌梗死），但卡培他滨诱发心脏毒性的报道较少。我们报告了一名诊断为局部晚期直肠腺癌的患者，该患者在术前放疗期间接受每日两次口服825mg/m²卡培他滨治疗时出现了症状性心动过缓和急性缺血。
