Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, Brazil; Genetic Service, IRCCS Burlo Garofolo and University of Trieste, Italy.
Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, Brazil.
Vaccine. 2010 Mar 2;28(10):2201-2206. doi: 10.1016/j.vaccine.2009.12.056. Epub 2010 Jan 5.
Dendritic cells (DCs)-based vaccine was demonstrated to increase HIV specific cellular immune response; however, in some HIV-infected patients, the response to the vaccine resulted to be not effective. In order to understand if the outcome of the vaccination may be influenced by the host's genome and natural immunity, we studied the innate immune genome of HIV-infected patients previously vaccinated with DCs. We identified 15 SNPs potentially associated with the response to the immuno-treatment and two SNPs significantly associated with the modulation of the response to the DC vaccine: MBL2 rs10824792 and NOS1 rs693534. These two SNPs were also studied in different ethnic groups (Brazilians, African and Caucasian) of HIV-infected, exposed uninfected and unexposed uninfected subjects. The HIV positive Caucasian patients were also characterized by different disease progressions. Our findings suggest that, independently and/or in addition to other variables, the host's genome could significantly contribute to the modulation of the response to the DC vaccine.
树突状细胞（DC）疫苗已被证明可增强 HIV 特异性细胞免疫应答；然而，在一些 HIV 感染患者中，疫苗的应答效果并不理想。为了了解疫苗接种的结果是否可能受到宿主基因组和天然免疫的影响，我们研究了先前接受 DC 疫苗免疫的 HIV 感染患者的固有免疫基因组。我们鉴定了 15 个可能与免疫治疗应答相关的单核苷酸多态性（SNP）和两个与 DC 疫苗应答调节显著相关的 SNP：MBL2 rs10824792 和 NOS1 rs693534。这两个 SNP 还在不同种族（巴西人、非洲人和高加索人）的 HIV 感染、暴露未感染和未暴露未感染的受试者中进行了研究。HIV 阳性的高加索患者也表现出不同的疾病进展。我们的研究结果表明，宿主基因组可能独立地（或与其他变量一起）显著影响 DC 疫苗的应答调节。
