Stanton G J, Langford M P, Baron S
Infect Immun. 1977 Nov;18(2):370-6. doi: 10.1128/iai.18.2.370-376.1977.
Five strains of enterovirus type 70 (E 70) and four of coxsackievirus type A 24 (CA 24) were studied for their sensitivity to interferon (IF), ability to induce IF, replication at various temperatures, and adaptability to human and mouse cell cultures. We found that isolates ranged from 0.01 to 16 times as sensitive to fibroblast IF as vesicular stomatitis virus, depending upon the cell type used and the multiplicity of infection. Most of the isolates induced no detectable IF; however, when induction occurred the titers were relatively low (5 to 300 U). Only E 70 virus isolates were adaptable to growth in L-cells. Replication of all viruses was inhibited approximately 90% at 37 to 39 degrees C depending upon the cell type. These results and the accessibility of the eye to application of IF and/or heat suggests the possibility of their use for treatment. The adaptation of certain E 70 viruses to mouse L-cells opens the possibility of development of a mouse model infection.
对5株肠道病毒70型（E70）和4株柯萨奇病毒A24型（CA24）进行了研究，观察它们对干扰素（IF）的敏感性、诱导IF的能力、在不同温度下的复制情况以及对人细胞和小鼠细胞培养物的适应性。我们发现，根据所使用的细胞类型和感染复数，分离株对成纤维细胞IF的敏感性是水疱性口炎病毒的0.01至16倍。大多数分离株未诱导出可检测到的IF；然而，当诱导发生时，效价相对较低（5至300 U）。只有E70病毒分离株能适应在L细胞中生长。根据细胞类型，所有病毒在37至39摄氏度时的复制被抑制约90%。这些结果以及眼睛易于应用IF和/或加热的情况提示了将它们用于治疗的可能性。某些E70病毒对小鼠L细胞的适应性为建立小鼠模型感染开辟了可能性。
