NYU Fertility Center, Langone Medical Center, New York, New York 10016, USA.
Fertil Steril. 2010 Oct;94(5):1689-92. doi: 10.1016/j.fertnstert.2009.11.010. Epub 2010 Jan 13.
To review a center's experience with cryopreserved embryos generated from donor eggs and to analyze their long-term disposition.
Retrospective analysis of donor egg cycles with cryopreserved embryos.
University-based IVF program.
PATIENT(S): Eight hundred twenty-nine women undergoing oocyte donation.
INTERVENTION(S): N/A.
MAIN OUTCOME MEASURE(S): Factors affecting the decision regarding disposition of donor frozen embryo transfer (dFET) and the association between fresh and dFET cycles.
RESULT(S): From January 2000 to December 2004, donor egg recipients underwent 829 fresh embryo transfer cycles that resulted in a 54% live birth rate. Of the 444 recipients who delivered, 177 (40%) also cryopreserved embryos at transfer; however, only 37 (21%) returned for a dFET by August 2009 and only 18 women had children from fresh and frozen transfers. In contrast, 128 of the 385 recipients who failed the fresh transfer (33%) cryopreserved embryos and 111 (87%) returned for a dFET. Of these, 44 had children from the dFET. Frozen cycle success rates between these recipient groups did not depend on fresh cycle outcome or prior parity.
CONCLUSION(S): Donor oocyte recipients often initiate treatment with a desire to cryopreserve embryos for future use and family expansion. However, our data demonstrates that most recipients with a child from the fresh transfer do not return to use their cryopreserved embryos. Although fresh transfer success correlated with embryo disposition, it did not correlate with the outcome of thawed embryo transfer.
回顾中心使用捐赠卵子生成的冷冻胚胎的经验，并分析其长期处置情况。
对冷冻胚胎的捐赠卵子周期进行回顾性分析。
大学基础 IVF 项目。
829 名接受卵子捐赠的女性。
无。
影响捐赠冷冻胚胎移植（dFET）处置决策的因素，以及新鲜和 dFET 周期之间的关联。
从 2000 年 1 月至 2004 年 12 月，接受捐赠卵子的患者进行了 829 个新鲜胚胎移植周期，活产率为 54%。在 444 名分娩的患者中，177 名（40%）在移植时也冷冻保存了胚胎；然而，直到 2009 年 8 月，只有 37 名（21%）回来进行 dFET，只有 18 名妇女通过新鲜和冷冻移植生育了孩子。相比之下，128 名新鲜移植失败的患者（33%）冷冻保存了胚胎，其中 111 名（87%）回来进行 dFET。其中 44 名通过 dFET 生育了孩子。这些患者组的冷冻周期成功率不依赖于新鲜周期的结果或先前的产次。
捐赠卵子的接受者通常开始治疗时希望冷冻保存胚胎以备将来使用和家庭扩展。然而，我们的数据表明，大多数有新鲜周期孩子的接受者不会回来使用他们的冷冻胚胎。虽然新鲜周期的成功与胚胎的处置相关，但与解冻胚胎移植的结果无关。
