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谷胱甘肽 S-转移酶 T1 基因的功能基因型与俄罗斯男性特发性不育症的风险增加密切相关。

The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men.

机构信息

Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia.

出版信息

Fertil Steril. 2010 Aug;94(3):1144-7. doi: 10.1016/j.fertnstert.2009.11.006. Epub 2010 Jan 13.

DOI:10.1016/j.fertnstert.2009.11.006
PMID:20056207
Abstract

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.

摘要

本研究旨在探讨谷胱甘肽 S-转移酶（GST）M1 和 T1 基因的无效多态性与包括 203 名不育男性和 227 名正常生育男性在内的俄罗斯人群中特发性男性不育症之间的关联。发现 GSTT1 基因的非缺失基因型与特发性男性不育症和弱精症的风险增加密切相关。

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