Reproductive Medical Center of Tianjin Medical University General Hospital, Tianjin, 300052, China.
J Assist Reprod Genet. 2013 Jan;30(1):131-41. doi: 10.1007/s10815-012-9907-7. Epub 2012 Dec 13.
Genes of different pathways regulate spermatogenesis, and the complexity of the spermatogenic process indicates that polymorphisms or mutations in these genes could cause male infertility. Published data on the association between the GSTM1 and GSTT1 polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed.
A total of 11 studies regarding GSTM1 and 9 studies regarding GSTT1 between 1999 and 2012 were identified through researching MEDLINE, EMBASE and the Chinese Biomedical Database. It was performed to obtain summary estimated odd ratios and 95 % confidence intervals of GSTM1 and GSTT1 for male infertility, with attention to study quality and publication bias.
Overall, a significant association was seen between GSTM1 (OR=1.20, 95 % CI=1.02-1.40, P(heterogeneity) =0.000, P=0.027) genotypes and male infertility. Significant associations were also observed in subgroups of Caucasian populations (OR=1.65, 95 %CI=1.16-2.34, P(heterogeneity) =0.006, P=0.005), but were not observed in Asian populations (OR=1.09, 95 % CI=0.72-1.65, P(heterogeneity) =0.054, P=0.697) when stratified by ethnicity. While there was no significant association was seen between GSTT1 (OR=1.00, 95 % CI=0.74-1.35, P(heterogeneity) =0.000, P=0.980) null genotypes and male infertility. Simultaneously, significant associations were not observed in subgroups of Caucasian populations (OR=0.94, 95 %CI=0.44-2.00, P(heterogeneity) =0.000, P=0.867) and Asian populations (OR=0.93, 95 % CI=0.46-1.87, P(heterogeneity) =0.002, P=0.838) when stratified by ethnicity.
Our results suggest the GSTM1 null genotype contributes to male infertility susceptibility, while GSTT1 gene polymorphisms are not associated with male infertility in our study.
不同途径的基因调节精子发生，而精子发生过程的复杂性表明，这些基因的多态性或突变可能导致男性不育。关于 GSTM1 和 GSTT1 多态性与男性不育风险之间的关联，已有研究结果尚无定论。为了更准确地评估这种关系，我们进行了荟萃分析。
通过检索 MEDLINE、EMBASE 和中国生物医学数据库，我们于 1999 年至 2012 年期间共找到了 11 项关于 GSTM1 和 9 项关于 GSTT1 的研究。我们对这些研究进行了综合分析，以获得 GSTM1 和 GSTT1 与男性不育之间的汇总估计比值比和 95%置信区间，并关注研究质量和发表偏倚。
总体而言，GSTM1（OR=1.20，95%CI=1.02-1.40，P(异质性)=0.000，P=0.027）基因型与男性不育之间存在显著关联。在白种人群亚组中也观察到了显著的关联（OR=1.65，95%CI=1.16-2.34，P(异质性)=0.006，P=0.005），但在亚洲人群亚组中没有观察到（OR=1.09，95%CI=0.72-1.65，P(异质性)=0.054，P=0.697）。按种族分层时，GSTM1 （OR=1.00，95%CI=0.74-1.35，P(异质性)=0.000，P=0.980）空基因型与男性不育之间没有显著关联。同时，在白种人群亚组（OR=0.94，95%CI=0.44-2.00，P(异质性)=0.000，P=0.867）和亚洲人群亚组（OR=0.93，95%CI=0.46-1.87，P(异质性)=0.002，P=0.838）中也没有观察到显著关联。
我们的结果表明，GSTM1 空基因型有助于男性不育的易感性，而 GSTT1 基因多态性与我们的研究中男性不育无关。
