Liao A H, Chou F I, Kuo Y C, Chen H W, Kai J J, Chang C W, Chen F D, Hwang J J
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Appl Radiat Isot. 2010 Mar;68(3):422-6. doi: 10.1016/j.apradiso.2009.12.033. Epub 2009 Dec 23.
A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4h post PBAD-lipiodol injection.
