用于硼中子俘获治疗优化的体内19F磁共振成像与波谱分析
In vivo 19F MR imaging and spectroscopy for the BNCT optimization.
作者信息
Porcari P, Capuani S, D'Amore E, Lecce M, La Bella A, Fasano F, Migneco L M, Campanella R, Maraviglia B, Pastore F S
机构信息
CNR-INFM SOFT, Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 2, Rome, Italy.
出版信息
Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S365-8. doi: 10.1016/j.apradiso.2009.03.065. Epub 2009 Mar 27.
The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine ((19)F-BPA) using (19)F MR Imaging ((19)F MRI) and Spectroscopy ((19)F MRS). The correlation between the results obtained by both techniques, (19)F MRI on rat brain and (19)F MRS on blood samples, showed the maximum (19)F-BPA uptake in C6 glioma model at 2.5h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of (19)F-BPA tumour intake was assessed using (19)F MRI.
本研究的目的是利用¹⁹F磁共振成像（¹⁹F MRI）和光谱学（¹⁹F MRS）在体内评估4-硼酰基-2-氟苯丙氨酸（¹⁹F-BPA）的硼生物分布和药代动力学。两种技术（大鼠脑¹⁹F MRI和血样¹⁹F MRS）所获结果之间的相关性表明，在输注后2.5小时，C6胶质瘤模型中¹⁹F-BPA摄取量最高，由此确定了最佳照射时间。此外，还利用¹⁹F MRI评估了L-多巴作为¹⁹F-BPA肿瘤摄取潜在增强剂的作用。
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