Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan.
Parkinsonism Relat Disord. 2010 May;16(4):249-51. doi: 10.1016/j.parkreldis.2009.12.004. Epub 2010 Jan 6.
Although hiccups may be a non-motor symptom of Parkinson's disease (PD), they have attracted little research attention to date.
To investigate the frequency of occurrence of hiccups in PD.
The presence of hiccups was evaluated using face-to-face interviews in 90 PD patients and 100 age-matched controls.
Eighteen (20%) of the PD patients and three (3%) of the control subjects reported frequent hiccups. The reported occurrence of hiccups was significantly higher in PD patients than controls. Nine patients noted that hiccups had appeared in the past, particularly around the onset of PD. One patient was admitted to our hospital because of intractable hiccups before a diagnosis of PD was made. Another eight patients reported the emergence of hiccups following the administration of antiparkinsonian drugs.
Our results suggest that hiccups are more frequent in PD patients than healthy controls. Further studies are required to determine whether hiccups are associated with intrinsic pathology, to dopamine replacement therapy, or both.
尽管打嗝可能是帕金森病（PD）的非运动症状，但迄今为止，它们还没有引起太多的研究关注。
调查 PD 患者中打嗝的发生频率。
通过面对面访谈，对 90 名 PD 患者和 100 名年龄匹配的对照组进行了打嗝的评估。
18 名（20%）PD 患者和 3 名（3%）对照组报告经常打嗝。PD 患者的报告发生率明显高于对照组。9 名患者指出，打嗝过去出现过，特别是在 PD 发病前后。一名患者因难治性打嗝被收入我院，此前尚未确诊 PD。另有 8 名患者报告说，在使用抗帕金森病药物后出现了打嗝。
我们的结果表明，PD 患者打嗝的频率高于健康对照组。需要进一步研究以确定打嗝是否与内在病理、多巴胺替代治疗或两者都有关。
