Shihabudheen P, Anver P C, Uvais N A, Mohammed T P
Department of Medicine, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.
Department of Neuropsychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.
J Family Med Prim Care. 2020 Mar 26;9(3):1749-1751. doi: 10.4103/jfmpc.jfmpc_1044_19. eCollection 2020 Mar.
Levodopa (L-dopa) is the most effective antiparkinsonian agent and is well tolerated at all stages of the disease. However, both motor and nonmotor adverse events are reported with the use of L-dopa. Electrolyte imbalances such as hyponatremia and hiccups with L-dopa/carbidopa are very rare. For the first time, we are reporting a case of L-dopa/carbidopa-induced hyponatremia and hiccup cooccurring in a 75-year-old male. He symptomatically improved after reducing the dose of levodopa/carbidopa, indicating a dose-dependent nature of these adverse events. Clinicians who prescribe L-dopa/carbidopa should be mindful of the potential for precipitating SIADH and hiccups, especially in elderly patients.
左旋多巴（L-多巴）是最有效的抗帕金森病药物，在疾病的各个阶段耐受性良好。然而，使用L-多巴会出现运动和非运动不良事件。L-多巴/卡比多巴引起的低钠血症和打嗝等电解质失衡非常罕见。我们首次报告一例75岁男性同时出现L-多巴/卡比多巴诱发的低钠血症和打嗝。减少左旋多巴/卡比多巴剂量后，他的症状有所改善，表明这些不良事件具有剂量依赖性。开具L-多巴/卡比多巴的临床医生应注意诱发抗利尿激素分泌异常综合征和打嗝的可能性，尤其是在老年患者中。
