Institut de Recherche pour le Développement, UR016, Characterization and control of vector populations, Montpellier, France.
Trends Parasitol. 2010 Mar;26(3):130-6. doi: 10.1016/j.pt.2009.12.001. Epub 2010 Jan 6.
In human malaria, transmission intensity is highly dependent on the vectorial capacity and competence of local mosquitoes. Most mosquitoes are dead ends for the parasite, and only limited ranges of Anopheles are able to transmit Plasmodium to humans. Research to understand the determinants of vectorial capacity and competence has greatly progressed in recent years; however, some aspects have been overlooked and the evolutionary pressures that affect them often neglected. Here, we review key factors of vectorial capacity and competence in Anopheles, with a particular focus on the most important malaria vector Anopheles gambiae. We aim to point out selection pressures exerted by Plasmodium on Anopheles to improve its own transmission and discuss how the parasite might shape the vector to its benefit.
在人类疟疾中，传播强度高度依赖于当地蚊子的媒介能力和媒介效能。大多数蚊子对寄生虫来说是死胡同，只有有限范围的按蚊能够将疟原虫传播给人类。近年来，人们为了理解媒介能力和媒介效能的决定因素进行了大量的研究；然而，有些方面被忽视了，而且影响它们的进化压力也经常被忽视。在这里，我们回顾了按蚊媒介能力和媒介效能的关键因素，特别关注最重要的疟疾媒介按蚊属冈比亚按蚊。我们的目的是指出疟原虫对按蚊施加的选择压力，以提高其自身的传播能力，并讨论寄生虫如何使媒介为其利益服务。
