Veterans Affairs Medical Center, Tomah, WI 54660, USA.
Epilepsy Behav. 2010 Feb;17(2):199-204. doi: 10.1016/j.yebeh.2009.11.018. Epub 2010 Jan 6.
Although it is known that depressive symptoms have significant impact on quality of life (QOL) in epilepsy and that atypical symptoms are common in interictal depression, less is known about the clinical significance of the atypical form of interictal depression as opposed to major depressive disorder (MDD). We compared quality of life among 30 patients with epilepsy (1) with major depressive disorder (group D), (2) with interictal dysphoric disorder (group ID), and (3) without MDD or IDD (group ND). The mean t scores on the 31-item Quality of Life in Epilepsy questionnaire were lower in groups D (20.3, 95% CI 9.02-31.7, n=3) and ID (38.7, 95% CI 34.2-43.2, n=19) compared with group ND (59.1, 95% CI 52.2-66.1, n=8). These results underscore the clinical significance of IDD that not only accounts for a large portion of mood symptoms in the population with epilepsy, but also is not adequately captured by the DSM-IV criteria for MDD.
虽然已知抑郁症状对癫痫患者的生活质量（QOL）有重大影响，且发作间期抑郁中常见非典型症状，但对于发作间期抑郁的非典型形式与重性抑郁障碍（MDD）相比的临床意义知之甚少。我们比较了 30 名癫痫患者（1）患有重性抑郁障碍（D 组），（2）患有发作间期恶劣心境障碍（ID 组），和（3）无 MDD 或 IDD（ND 组）的生活质量。在 31 项癫痫生活质量问卷中，D 组（20.3，95%置信区间 9.02-31.7，n=3）和 ID 组（38.7，95%置信区间 34.2-43.2，n=19）的平均 t 分数均低于 ND 组（59.1，95%置信区间 52.2-66.1，n=8）。这些结果强调了 IDD 的临床意义，它不仅在癫痫患者人群中占很大一部分情绪症状，而且也不能被 DSM-IV 对 MDD 的标准充分捕捉到。
