Kanner Andres M
Department of Neurological Sciences, Rush Medical College, Rush University Medical Center, Chicago, Illinois 60612, USA.
Epilepsia. 2007;48 Suppl 9:20-2. doi: 10.1111/j.1528-1167.2007.01395.x.
Mood disorders (MD) are a frequent comorbidity of epilepsy with a negative impact on quality of life. The higher prevalence of MD in people with epilepsy (PWE) is most likely a reflection of a bidirectional relation between the two conditions, and common pathogenic mechanisms. Treatment of MD in PWE is safe with selective serotonin reuptake inhibitor (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), but nonpsychiatrists need to know when to refer these patients to a psychiatrist for further evaluation and treatment.
情绪障碍（MD）是癫痫常见的共病情况，对生活质量有负面影响。癫痫患者（PWE）中MD的较高患病率很可能反映了这两种病症之间的双向关系以及共同的致病机制。使用选择性5-羟色胺再摄取抑制剂（SSRIs）和5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRIs）治疗PWE的MD是安全的，但非精神科医生需要知道何时将这些患者转介给精神科医生进行进一步评估和治疗。
