Indiana University School of Nursing, 1111 Middle Drive, Indianapolis, IN 46202, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):201-10. doi: 10.1158/1055-9965.EPI-09-0569.
Low-income African American women face numerous barriers to mammography screening. We tested the efficacy of a combined interactive computer program and lay health advisor intervention to increase mammography screening.
In this randomized, single blind study, participants were 181 African American female health center patients of ages 41 to 75 years, at < or =250% of poverty level, with no breast cancer history, and with no screening mammogram in the past 15 months. They were assigned to either (a) a low-dose comparison group consisting of a culturally appropriate mammography screening pamphlet or (b) interactive, tailored computer instruction at baseline and four monthly lay health advisor counseling sessions. Self-reported screening data were collected at baseline and 6 months and verified by medical record.
For intent-to-treat analysis of primary outcome (medical record-verified mammography screening, available on all but two participants), the intervention group had increased screening to 51% (45 of 89) compared with 18% (16 of 90) for the comparison group at 6 months. When adjusted for employment status, disability, first-degree relatives with breast cancer, health insurance, and previous breast biopsies, the intervention group was three times more likely (adjusted relative risk, 2.7; 95% confidence interval, 1.8-3.7; P < 0.0001) to get screened than the low-dose comparison group. Similar results were found for self-reported mammography stage of screening adoption.
The combined intervention was efficacious in improving mammography screening in low-income African American women, with an unadjusted effect size (relative risk, 2.84) significantly higher (P < 0.05) than that in previous studies of each intervention alone.
低收入的非裔美国妇女在接受乳房 X 光筛检方面面临着诸多障碍。我们测试了一种结合使用互动式计算机程序和初级卫生保健顾问干预措施来增加乳房 X 光筛检的效果。
在这项随机、单盲研究中,参与者为年龄在 41 至 75 岁之间、收入低于贫困线 250%的、没有乳腺癌病史且在过去 15 个月内没有接受过筛检乳房 X 光检查的 181 名非裔美国女性卫生保健中心患者。她们被分配到(a)低剂量对照组,包括一份文化上适宜的乳房 X 光筛检手册,或(b)基线时的互动式、个性化计算机指导以及 4 次每月初级卫生保健顾问咨询。在基线和 6 个月时收集自我报告的筛检数据,并通过医疗记录加以核实。
对主要结局(所有参与者除 2 人之外均可用医疗记录核实的乳房 X 光筛检)进行意向治疗分析,干预组的筛检率从基线时的 18%(90 名中的 16 名)增至 6 个月时的 51%(89 名中的 45 名)。经调整就业状况、残疾、一级乳腺癌亲属、医疗保险和以往乳房活检情况后,干预组接受筛检的可能性是低剂量对照组的 3 倍(调整后的相对危险度,2.7;95%可信区间,1.8-3.7;P<0.0001)。自我报告的筛检阶段采用情况也得到了类似的结果。
该联合干预措施在提高低收入非裔美国妇女的乳房 X 光筛检率方面是有效的,其未调整的效果大小(相对危险度,2.84)显著高于(P<0.05)以往每项干预措施单独使用的研究。