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具有乳腺癌个人病史者的影像学监测选择:专家小组叙事性综述。

Imaging Surveillance Options for Individuals With a Personal History of Breast Cancer: Expert Panel Narrative Review.

机构信息

Department of Radiology, University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Ave E, LG-200, Seattle, WA 98040.

Department of Radiology, University of Vermont Larner College of Medicine, University of Vermont Cancer Center, Burlington, VT.

出版信息

AJR Am J Roentgenol. 2022 Dec;219(6):854-868. doi: 10.2214/AJR.22.27635. Epub 2022 May 11.

Abstract

Annual surveillance mammography is recommended for breast cancer survivors on the basis of observational studies and meta-analyses showing reduced breast cancer mortality and improved quality of life. However, breast cancer survivors are at higher risk of subsequent breast cancer and have a fourfold increased risk of interval breast cancers compared with individuals without a personal history of breast cancer. Supplemental surveillance modalities offer increased cancer detection compared with mammography alone, but utilization is variable, and benefits must be balanced with possible harms of false-positive findings. In this review, we describe the current state of mammographic surveillance, summarize evidence for supplemental surveillance in breast cancer survivors, and explore a risk-based approach to selecting surveillance imaging strategies. Further research identifying predictors associated with increased risk of interval second breast cancers and development of validated risk prediction tools may help physicians and patients weigh the benefits and harms of surveillance breast imaging and decide on a personalized approach to surveillance for improved breast cancer outcomes.

摘要

年度监测乳房 X 光检查是基于观察性研究和荟萃分析推荐给乳腺癌幸存者的,这些研究和分析表明可以降低乳腺癌死亡率和提高生活质量。然而,与没有乳腺癌个人病史的个体相比,乳腺癌幸存者有更高的后续乳腺癌风险,并且间隔性乳腺癌的风险增加了四倍。与单独乳房 X 光检查相比,补充监测方法可提高癌症检测率,但利用率存在差异,并且必须权衡假阳性结果可能带来的益处和危害。在这篇综述中,我们描述了当前乳房 X 光监测的情况,总结了乳腺癌幸存者补充监测的证据,并探讨了一种基于风险的方法来选择监测成像策略。进一步的研究确定了与间隔性第二乳腺癌风险增加相关的预测因素,并开发了经过验证的风险预测工具,这可能有助于医生和患者权衡监测乳房成像的益处和危害,并决定采用个性化的监测方法来改善乳腺癌的预后。

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