Roberts D, Honcharik N, Sitar D S, Tenenbein M
Department of Medicine, University of Manitoba, Winnipeg.
J Toxicol Clin Toxicol. 1991;29(1):45-52. doi: 10.3109/15563659109038596.
We describe a 38 year-old female who ingested 900 mg of diltiazem. She experienced hypotension, bradycardia and heart block but responded well to supportive care that included normal saline infusion and vasopressors. Calcium administration was not beneficial. Serial plasma concentrations of diltiazem, N-demethyldiltiazem and desacetyldiltiazem were quantified. By comparing the elimination half-life for diltiazem with historical controls, it is concluded that multiple dose charcoal therapy was not beneficial for our patient.
我们描述了一名38岁女性，她摄入了900毫克地尔硫䓬。她出现了低血压、心动过缓和心脏传导阻滞，但对包括输注生理盐水和使用血管加压药在内的支持性治疗反应良好。钙剂治疗并无益处。对血浆中地尔硫䓬、N-去甲基地尔硫䓬和去乙酰地尔硫䓬的浓度进行了连续定量测定。通过将该患者地尔硫䓬的消除半衰期与既往对照进行比较，得出结论：多剂量活性炭疗法对我们的患者并无益处。
