Ferner R E, Odemuyiwa O, Field A B, Walker S, Volans G N, Bateman D N
Regional Clinical Pharmacology Unit, Freeman Hospital, Newcastle upon Tyne, UK.
Hum Toxicol. 1989 Nov;8(6):497-9. doi: 10.1177/096032718900800611.
A 50-year-old man with ischaemic heart disease took 98 tablets of diltiazem 60 mg with alcohol. He developed a junctional bradycardia, hypotension and reduced cardiac function refractory to intravenous calcium gluconate. He survived with temporary cardiac pacing and infusion of dopamine. As much as half the dose was vomited back, but nonetheless the plasma diltiazem concentration reached 6090 micrograms/l before falling mono-exponentially with a half-life of 8.6 h. Sinus rhythm returned when the plasma concentration of diltiazem was around 750 micrograms/l. Standard resuscitative procedures sufficed to treat massive diltiazem overdosage.
一名患有缺血性心脏病的50岁男性，服用了98片60毫克的地尔硫䓬并饮酒。他出现了交界性心动过缓、低血压和心脏功能减退，静脉注射葡萄糖酸钙无效。他通过临时心脏起搏和多巴胺输注得以存活。多达一半的剂量被吐了出来，但尽管如此，地尔硫䓬血浆浓度在呈单指数下降（半衰期为8.6小时）之前仍达到了6090微克/升。当地尔硫䓬血浆浓度约为750微克/升时，窦性心律恢复。标准的复苏程序足以治疗大量地尔硫䓬过量中毒。
