Montague D K, Lakin M M, VanderBurg Mendendorp S, Tesar L J
Center for Sexual Function, Cleveland Clinic Foundation, Ohio.
J Urol. 1991 Apr;145(4):768-71. doi: 10.1016/s0022-5347(17)38446-x.
Infusion pharmacocavernosometry and nocturnal penile tumescence findings were compared in 50 men with erectile dysfunction of either organic or psychogenic etiology. Of the men 29 had abnormal and 21 had normal nocturnal penile tumescence. Infusion pharmacocavernosometry parameters (equilibrium pressure, maintenance flow rate and 30-second pressure fall) were compared to nocturnal penile tumescence status (normal versus abnormal). When traditional normal values were used for infusion pharmacocavernosometry parameters poor correlation with nocturnal penile tumescence status was found. When new cutpoints for infusion pharmacocavernosometry parameters were chosen a stronger correlation was noted. This study suggests that when vasoactive drugs are injected intracavernously for diagnostic purposes, anxiety and/or the absence of sexual stimulation following the injection may prevent complete cavernous smooth muscle relaxation resulting in falsely abnormal values. Therefore, over reliance on infusion pharmacocavernosometry as a single test for evaluation and treatment decisions concerning erectile dysfunction should be avoided.
对50名患有器质性或心因性病因勃起功能障碍的男性进行了灌注海绵体测压和夜间阴茎勃起监测结果的比较。在这些男性中，29人夜间阴茎勃起异常，21人正常。将灌注海绵体测压参数（平衡压力、维持流速和30秒压力下降）与夜间阴茎勃起状态（正常与异常）进行了比较。当使用传统正常值作为灌注海绵体测压参数时，发现与夜间阴茎勃起状态的相关性较差。当选择新的灌注海绵体测压参数切点时，发现相关性更强。这项研究表明，当为诊断目的向海绵体内注射血管活性药物时，注射后的焦虑和/或缺乏性刺激可能会阻止海绵体平滑肌完全松弛，从而导致错误的异常值。因此，应避免过度依赖灌注海绵体测压作为评估和治疗勃起功能障碍决策的单一测试。
