University of Michigan, Ann Arbor, MI, USA.
Qual Life Res. 2010 Mar;19(2):207-18. doi: 10.1007/s11136-009-9576-x.
Psychosocial outcomes derived from standardized and disease-specific measures are often used in pediatric oncology; however, the reliability, validity and utility of these instruments in adult survivors of childhood cancer have yet to be established.
To develop and evaluate a new instrument that measures aspects of long-term survivorship not measured by existing tools.
A new candidate instrument--the Impact of Cancer for childhood cancer survivors (IOC-CS)--was administered to childhood cancer survivors aged 18-39 who were 21 years of age or younger when diagnosed with cancer. Psychometric properties of newly derived scales were assessed.
Factor analyses of items derived eight new and specific subscales: Life Challenges, Body/Health, Talking With Parents, Personal Growth, Thinking/Memory Problems, Health Literacy, Socializing and Financial Problems. Internal consistency measurements for these subscales ranged from 0.70 to 0.86. Expected associations within and among the IOC-CS subscales and standardized measures of health-related quality of life (HRQOL) were observed, as were some unexpected findings.
Psychometric analyses indicated that this initial version of the IOC-CS measures distinct and relevant constructs for young adult survivors of childhood cancer. Future work is necessary to confirm the responsiveness and further validate the instrument in multiple and representative samples.
标准化和疾病特异性测量得出的心理社会结果常用于儿科肿瘤学；然而，这些工具在儿童癌症成年幸存者中的可靠性、有效性和实用性尚未确定。
开发和评估一种新的工具，用于测量现有工具未测量的长期生存方面。
对 18-39 岁的儿童癌症幸存者进行了一项新的候选工具——癌症对儿童癌症幸存者的影响（IOC-CS）的评估，这些幸存者在诊断癌症时年龄在 21 岁或以下。评估了新衍生量表的心理计量学特性。
对项目的因子分析得出了八个新的和特定的子量表：生活挑战、身体/健康、与父母交谈、个人成长、思维/记忆问题、健康素养、社交和财务问题。这些子量表的内部一致性测量值范围为 0.70 至 0.86。在 IOC-CS 子量表内部和之间以及与健康相关的生活质量（HRQOL）的标准化测量之间观察到了预期的关联，以及一些意外的发现。
心理计量学分析表明，IOC-CS 的这个初始版本测量了儿童癌症年轻成年幸存者的独特和相关结构。未来的工作需要在多个代表性样本中确认工具的响应能力并进一步验证。
