Kobayashi Nobuaki, Watanuki Yuji, Miyazawa Naoki, Kudo Makoto, Inoue Satoshi, Sato Takashi, Mishina Kei, Takahashi Hiroshi, Kaneko Takeshi, Ishigatsubo Yoshiaki
Department of Respiratory Medicine, Yokohama City University Hospital.
Nihon Kokyuki Gakkai Zasshi. 2009 Dec;47(12):1063-9.
To elucidate the preventive effect of 23-valent pneumococcal polysaccharide vaccine (PV) on drug-resistant Streptococcus pneumoniae.
Participants (outpatients, over 60 years of age, and with chronic lung disease) were interviewed and divided into two groups: the PV-vaccinated group (n=722) and the non-vaccinated group (n=872). The antimicrobial susceptibility and the genotype of antibiotic-resistant genes among the isolated pneumococcal strains from sputum before and after vaccination were studied.
The number of the isolated strains was as follows: prior to the vaccination, 24 isolates in the vaccinated group, 18 isolates in the non-vaccinated group; after vaccination (within 5 years), 53 isolates in the vaccinated group, 46 isolated in the non-vaccinated group. The PV decreased the frequency of Penicillin G-resistant strains successfully (from 16.7 to 7.5%) in the vaccinated group while the frequency increased (from 5.5 to 15.2%) in the non-vaccinated group during the same period. In genetic analysis, the rates of strains with altered pbpla, pbp2x and pbp2b were decreased in the vaccinated group than the non-vaccinated group (28.6% versus 53.3%).
The 23-valent pneumococcal polysaccharide vaccine may have a preventive effect against drug-resistant Streptococcus pneumoniae.
阐明23价肺炎球菌多糖疫苗（PV）对耐药肺炎链球菌的预防作用。
对参与者（60岁以上的门诊患者且患有慢性肺病）进行访谈并分为两组：接种PV疫苗组（n = 722）和未接种疫苗组（n = 872）。研究了接种疫苗前后从痰液中分离出的肺炎球菌菌株的抗菌药敏性及抗生素耐药基因的基因型。
分离出的菌株数量如下：接种疫苗前，接种疫苗组有24株，未接种疫苗组有18株；接种疫苗后（5年内），接种疫苗组有53株，未接种疫苗组有46株。在同一时期，PV成功降低了接种疫苗组中耐青霉素G菌株的频率（从16.7%降至7.5%），而未接种疫苗组中该频率升高（从5.5%升至15.2%）。在基因分析中，接种疫苗组中pbpla、pbp2x和pbp2b发生改变的菌株比例低于未接种疫苗组（28.6%对53.3%）。
23价肺炎球菌多糖疫苗可能对耐药肺炎链球菌具有预防作用。
