Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Eötvös Loránd University, Budapest 112, POB. 32, H-1518 Hungary.
Langmuir. 2010 Feb 2;26(3):1440-4. doi: 10.1021/la903373g.
Biodegradable polyesters such poly(lactic acid) and poly(lactic/glycolic acid) (PLGA) copolymers are preferred biomaterials and used among others as drug delivery systems, although their surface hydrophobicity limits their application. In this work, chemical modification of the PLGA surface was developed by coupling of either linear or starlike poly(ethylene glycol) (PEG) molecules via chemical bonds to the PLGA surface following amino functionalization as a first step to improve its biocompatibility. The chemical attachment was followed by detailed X-ray photoelectron spectroscopy (XPS) studies. It was shown that substantial modification can be achieved by linear PEG, but even higher surface coverage with hydrophilic groups can be obtained when the six-armed PEG is applied with the additional advantage of possible further functionalization via free amino groups available on the surface of the latter. As a final goal, a significant increase of water wettability together with reduced protein adsorption was achieved on PEG-coupled PLGA surfaces.
可生物降解的聚酯，如聚乳酸（PLA）和聚乳酸/羟基乙酸共聚物（PLGA），是首选的生物材料，它们被用作药物输送系统等，尽管它们的表面疏水性限制了它们的应用。在这项工作中，通过化学键将线性或星形聚乙二醇（PEG）分子偶联到 PLGA 表面，对 PLGA 表面进行化学修饰，首先将其氨基功能化，以提高其生物相容性。化学接枝后，进行了详细的 X 射线光电子能谱（XPS）研究。结果表明，线性 PEG 可以实现实质性的修饰，但当应用六臂 PEG 时，可以获得更高的亲水性基团表面覆盖率，其额外的优点是通过后者表面上可用的游离氨基基团，有可能进一步进行功能化。作为最终目标，在 PEG 偶联的 PLGA 表面上实现了显著提高的水润湿性和减少的蛋白质吸附。
