Rittig S, Arentsen J, Sørensen K, Matthiesen T, Dupont E
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Mov Disord. 1991;6(1):21-8. doi: 10.1002/mds.870060105.
The hemodynamic effects of triglycyl-lysine-vasopressin (TGLVP) were investigated in a single-blind study in seven patients with chronic orthostatic hypotension and parkinsonism. Blood pressure, heart rate, and stroke volume were measured in the supine position before and after bolus injection of either placebo or TGLVP (5.0, 7.5, or 10.0 micrograms/kg of body weight). After 40 min in the supine position, the patients were head-up tilted to 45 degrees for 20 min. All patients underwent four tilt studies with different medication. The TGLVP increased supine blood pressure by approximately 25% and total peripheral resistance by approximately 46%, and reduced heart rate by approximately 13%. No changes in supine stroke volume or cardiac output were seen. The TGLVP slightly reduced the relative fall in blood pressure and increased heart rate during the tilt. After TGLVP, blood pressure levels during tilt were similar to supine levels prior to medication. The TGLVP did not change the effects of tilt on stroke volume or cardiac output. Only few and mild side effects were experienced and no cardiotoxic effects were observed. In conclusion, TGLVP showed marked blood pressure effects of very small doses in this category of patients. The clinical effects of TGLVP and other vasopressor-specific analogs of vasopressin should be tested in these patients.
在一项针对7例慢性体位性低血压合并帕金森病患者的单盲研究中，对三甘氨酰赖氨酸加压素（TGLVP）的血流动力学效应进行了研究。在推注安慰剂或TGLVP（5.0、7.5或10.0微克/千克体重）前后，测量患者仰卧位时的血压、心率和每搏输出量。在仰卧位40分钟后，将患者头部抬高至45度并保持20分钟。所有患者均接受了4次使用不同药物的倾斜试验。TGLVP使仰卧位血压升高约25%，总外周阻力增加约46%，心率降低约13%。仰卧位每搏输出量或心输出量未见变化。TGLVP在倾斜过程中轻微降低了血压的相对下降幅度并增加了心率。使用TGLVP后，倾斜过程中的血压水平与用药前的仰卧位血压水平相似。TGLVP未改变倾斜对每搏输出量或心输出量的影响。仅出现了少数轻微的副作用，未观察到心脏毒性作用。总之，在这类患者中，TGLVP显示出非常小的剂量就具有显著的血压效应。TGLVP和其他血管加压素特异性类似物的临床效果应在这些患者中进行测试。
