Kochar M S
Am J Kidney Dis. 1985 Jul;6(1):49-52. doi: 10.1016/s0272-6386(85)80037-8.
Previous investigations have demonstrated that the postural stimulation of arginine vasopressin (AVP) release is reduced in patients with Shy-Drager syndrome. We studied the effects of lypressin nasal spray on hemodynamic parameters in ten patients with chronic orthostatic hypotension. Heart rate, blood pressure, and stroke volume were measured at 0 degrees, 45 degrees and 70 degrees tilt before and one-half hour after two nasal sprays (four United States Pharmacopeia posterior pituitary pressor units, 7.4 micrograms) of lypressin. Lypressin did not significantly alter the effect of tilt on heart rate, stroke volume, and cardiac output but increased the blood pressure and total peripheral resistance. AVP analogues should be tested for treating chronic postural hypotension.
先前的研究表明，患有Shy-Drager综合征的患者中，精氨酸加压素（AVP）释放的体位刺激作用减弱。我们研究了赖氨酸加压素鼻喷雾剂对10例慢性直立性低血压患者血流动力学参数的影响。在给予两次赖氨酸加压素鼻喷雾剂（四个美国药典垂体后叶升压单位，7.4微克）之前及之后半小时，分别在0度、45度和70度倾斜位测量心率、血压和每搏输出量。赖氨酸加压素并未显著改变倾斜对心率、每搏输出量和心输出量的影响，但提高了血压和总外周阻力。应测试AVP类似物治疗慢性体位性低血压的效果。
