Department of Anaesthesia, Royal Hampshire and County Hospital, Winchester, United Kingdom.
J Dermatolog Treat. 2010 Nov;21(6):361-2. doi: 10.3109/09546630903341978.
A 16-year-old male started on isotretinoin 80 mg daily for acne developed persistent headache 3 weeks later, with myoclonus and confusion 10 weeks later. During initial hospital assessment his Glasgow Coma Scale score fell acutely to 8 and he required ventilation. Brain imaging and cerebrospinal fluid (CSF) analysis were normal and an electroencephalogram (EEG) showed features of encephalopathy. No cause was found. He was extubated after 24 hours and made a full recovery. This is the first report of a generalized encephalopathy thought likely to be due to isotretinoin.
一位 16 岁男性因痤疮开始每日服用异维 A 酸 80mg，3 周后出现持续性头痛，10 周后出现肌阵挛和意识混乱。在最初的医院评估中，他的格拉斯哥昏迷评分急剧下降到 8，需要通气。脑成像和脑脊液（CSF）分析正常，脑电图（EEG）显示脑病特征。未发现病因。他在 24 小时后拔管并完全康复。这是首例被认为可能是由异维 A 酸引起的全身性脑病的报告。
