Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA.
Dev Cell. 2009 Dec;17(6):745-6. doi: 10.1016/j.devcel.2009.11.007.
Repression of transposable elements is crucial for the survival of germ cells. In this issue of Developmental Cell, Shoji et al. provide evidence that a Tudor domain protein TDRD9 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.
转座元件的抑制对于生殖细胞的存活至关重要。在本期《发育细胞》中，Shoji 等人提供了证据，表明一个含有 Tudor 结构域的蛋白 TDRD9 与 MIWI2 合作，特异性地沉默雄性小鼠胚胎生殖细胞中的 LINE-1 转座子。
