有丝分裂中的 Wnt 信号传导。
Wnt signaling in mitosis.
机构信息
Institute of Molecular and Cell Biology (IMCB), Cell Division and Cancer Laboratory (PRK), 61 Biopolis Drive, Proteos #03-09, Singapore 138673, Republic of Singapore.
出版信息
Dev Cell. 2009 Dec;17(6):749-50. doi: 10.1016/j.devcel.2009.12.001.
PMID:20059944
Abstract
Previously, the connection between cell proliferation and Wnt signaling focused on transcriptional activation of cyclin D1 and c-myc, which control the G1/S transition of the cell cycle. In this issue of Developmental Cell, the Niehrs group demonstrates mitotic activation of Wnt signaling by a novel Cdk/cyclin complex containing Cdk14 (PFTK1) and cyclin Y.
摘要
此前，细胞增殖与 Wnt 信号之间的联系主要集中在细胞周期 G1/S 转换的 cyclin D1 和 c-myc 的转录激活上。在本期《发育细胞》中，Niehrs 小组证明了含有 Cdk14（PFTK1）和 cyclin Y 的新型 Cdk/周期蛋白复合物使 Wnt 信号在有丝分裂中被激活。
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