Fernández S, González C, Díaz F, Fueyo A M, Gutiérrez J M, Patterson A M
Departamento de Biología Funcional, Fisiología, Facultad de Medicina, Universidad de Oviedo, Spain.
Int J Vitam Nutr Res. 1996;66(4):393-9.
The effect of ingestion of enriched oil diets (soybean and olive) during two generations on some cardiovascular and biochemical parameters was measured in male rats. The animals (dams and pups) were fed with 3 different diets: standard diet, standard diet enriched with 7% of soybean oil and standard diet enriched with 7% of olive oil. At 2.5 months of age, male rats (first and second generation) after remaining in metabolic cages for a period of 10 days, were then anaesthetized, and body and heart weight, systolic, diastolic, mean blood pressure and heart rate, total-cholesterol, HDL-cholesterol, triglycerides, glucose and insulin were measured. Experimental diets produced over-weight only in the second generation. Blood pressure values were within normal limits, but in animals eating soybean oil these parameters were significantly increased in the second generation. While the concentrations of cholesterol, triglycerides and insulin in the second generation were significantly greater in experimental animals, and the concentrations of HDL-cholesterol and glucose were lower than in the controls, only the concentration of insulin was significantly greater in the experimental animals in the first generation. Plasmatic value of cholesterol was significantly increased in animals eating olive oil and plasmatic value of glucose was significantly decreased in animals eating soybean oil in the first generation. These results suggest that chronic ingestion of enriched oil diets negatively affects a number of key parameters implicated in the regulation of lipid and carbohydrate metabolism in male rats.
在雄性大鼠中测量了连续两代摄入富含油脂的饮食（大豆油和橄榄油）对一些心血管和生化参数的影响。动物（母鼠和幼鼠）被喂食3种不同的饮食：标准饮食、富含7%大豆油的标准饮食和富含7%橄榄油的标准饮食。在2.5月龄时，雄性大鼠（第一代和第二代）在代谢笼中饲养10天后，进行麻醉，然后测量体重、心脏重量、收缩压、舒张压、平均血压和心率、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、葡萄糖和胰岛素。实验饮食仅在第二代导致超重。血压值在正常范围内，但食用大豆油的动物在第二代中这些参数显著增加。虽然第二代实验动物中的胆固醇、甘油三酯和胰岛素浓度显著高于对照组，而高密度脂蛋白胆固醇和葡萄糖浓度低于对照组，但第一代实验动物中只有胰岛素浓度显著高于对照组。第一代中，食用橄榄油的动物血浆胆固醇值显著升高，食用大豆油的动物血浆葡萄糖值显著降低。这些结果表明，长期摄入富含油脂的饮食会对雄性大鼠脂质和碳水化合物代谢调节中涉及的一些关键参数产生负面影响。
