School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
Curr Opin Immunol. 2010 Feb;22(1):20-7. doi: 10.1016/j.coi.2009.12.002. Epub 2010 Jan 7.
In recent years the importance of the localisation and trafficking of Toll-like receptors (TLRs) and their adaptors within the cell has become apparent. Localisation and trafficking of both cell surface and endosomal TLRs, alongside their adaptors, appears to play an important role not only in ligand recognition but also in the downregulation of signaling following ligand stimulation. Chaperones, such as gp96, PRAT4A and Unc93B1 play a role in TLR localisation. TLR4 cycles between the Golgi and the plasma membrane until engaged by LPS. The MyD88-dependent pathway is then initiated at the plasma membrane, followed by the movement of the TLR4 complex into the endosome where the MyD88-independent pathway is activated. Several proteins, including Triad3A and TAG appear to be involved in the movement of TLR4 to the lysosome for degradation.
近年来，Toll 样受体 (TLRs) 及其衔接蛋白在细胞内的定位和运输的重要性变得明显。细胞表面和内体 TLRs 及其衔接蛋白的定位和运输似乎不仅在配体识别中而且在配体刺激后的信号下调中发挥重要作用。伴侣蛋白，如 gp96、PRAT4A 和 Unc93B1，在 TLR 定位中发挥作用。TLR4 在高尔基氏体和质膜之间循环，直到与 LPS 结合。然后在质膜上启动 MyD88 依赖性途径，随后 TLR4 复合物进入内体，其中激活 MyD88 非依赖性途径。几种蛋白质，包括 Triad3A 和 TAG，似乎参与 TLR4 向溶酶体降解的运动。
