Department of Physiology, PO Box 13F, Monash University, Clayton, Victoria 3800, Australia.
Trends Endocrinol Metab. 2010 Apr;21(4):255-60. doi: 10.1016/j.tem.2009.11.010. Epub 2010 Jan 7.
Reproductive function depends on the stimulatory action of gonadotropin-releasing hormone (GnRH), secreted by the brain. Original work in birds identified and isolated a peptide that inhibits gonadotropin release, named gonadotropin inhibitory hormone (GnIH). There is no evidence for a similar factor operant in mammals. This mammalian orthologue of GnIH has been named RFamide-related peptide (RFRP), and negatively regulates GnRH function and gonadotropin secretion. In particular, mammalian GnIH inhibits the function of GnRH cells and acts at the level of gonadotropes. It appears to play a major role in seasonal regulation of reproduction and also to be involved in regulation of stress and food intake.
生殖功能取决于由脑分泌的促性腺激素释放激素（GnRH）的刺激作用。鸟类的原始研究鉴定并分离出一种抑制促性腺激素释放的肽，命名为促性腺激素抑制激素（GnIH）。在哺乳动物中没有类似的作用因子的证据。这种哺乳动物 GnIH 的同源物被命名为 RFamide 相关肽（RFRP），并负调控 GnRH 功能和促性腺激素的分泌。特别是，哺乳动物 GnIH 抑制 GnRH 细胞的功能，并在促性腺激素细胞水平上发挥作用。它似乎在季节性生殖调控中起主要作用，并且还参与应激和摄食的调控。
