Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
Cardiovasc Pathol. 2011 Jan-Feb;20(1):63-7. doi: 10.1016/j.carpath.2009.11.004. Epub 2010 Jan 8.
We report the clinical, pathological, and immunohistochemical features of four primary malignant cardiac tumors identified at the Department of Pathology, Rigshospitalet, Denmark. A panel of immunohistochemical markers for classification is proposed.
Between 2000 and 2008, four patients with malignant cardiac tumors were treated at our hospital. We retrospectively reviewed the medical records and evaluated the patient characteristics and treatment.
Three patients presented with severe dyspnea; one patient presented with chest pain. Transthoracic echocardiography demonstrated, in all four cases, abnormal masses in the atria. The cases were, based on morphological features and immunoprofile, classified as myogenic sarcoma (two cases), undifferentiated pleomorphic sarcoma, and leiomyosarcoma. Three of the patients received orthotopic heart transplantation. One patient survived 6.5 years after the diagnosis, and two patients are still alive 2 and 3 years after being diagnosed, respectively.
All four cases were sarcomas. A limited number of immunohistochemical markers can be used in order to define a specific line of differentiation. In this small study, three of the patients were offered orthotopic heart transplantation, and the survival times were generally longer than in most series.
我们报告了在丹麦 Rigshospitalet 病理科发现的 4 例原发性心脏恶性肿瘤的临床、病理和免疫组化特征。提出了一组用于分类的免疫组化标志物。
在 2000 年至 2008 年间，我们医院收治了 4 名患有恶性心脏肿瘤的患者。我们回顾性地复习了病历，并评估了患者的特征和治疗情况。
3 例患者出现严重呼吸困难；1 例患者出现胸痛。经胸超声心动图在所有 4 例患者中均显示心房内异常肿块。根据形态学特征和免疫组化特征，将这些病例分类为肌源性肉瘤（2 例）、未分化多形性肉瘤和平滑肌肉瘤。3 例患者接受了原位心脏移植。1 例患者在诊断后存活了 6.5 年，另外 2 例患者分别在诊断后存活了 2 年和 3 年。
所有 4 例均为肉瘤。可以使用少数免疫组化标志物来确定特定的分化方向。在这项小型研究中，3 名患者接受了原位心脏移植，生存时间通常比大多数系列报道的要长。
