State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100176, PR China.
Antiviral Res. 2010 Mar;85(3):559-61. doi: 10.1016/j.antiviral.2009.12.010. Epub 2010 Jan 7.
In March and April 2009, an entirely novel influenza A (H1N1) virus (NIAV) emerged in Mexico and the USA. During the subsequent months, the virus rapidly spread all over the world by person-to-person transmission. In this report, RNA interference (RNAi) was used as an antiviral agent to inhibit NIAV replication in A549 cells. Ten small interfering RNAs (siRNAs) targeting extremely conserved regions among multiple NIAV genomes could effectively block the replication of NIAV strain A/Beijing/01/2009 (H1N1) in A549 cells. This study may be useful to confront the sudden emergence of NIAV infection.
2009 年 3 月至 4 月，一种全新的甲型 H1N1 流感病毒（NIAV）在墨西哥和美国出现。在随后的几个月里，该病毒通过人际传播迅速在全球范围内传播。在本报告中，RNA 干扰（RNAi）被用作抗病毒药物，以抑制 A549 细胞中的 NIAV 复制。十种针对多个 NIAV 基因组中高度保守区域的小干扰 RNA（siRNA）能够有效阻断 A/Beijing/01/2009（H1N1）NIAV 株在 A549 细胞中的复制。这项研究可能有助于应对 NIAV 感染的突然出现。
