HPMA 共聚物的分子成像：在细胞、小鼠和人体中观察药物递送。

Molecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man.

机构信息

Department of Biomedical Engineering, Wickenden Building, Room 427, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7207, USA.

出版信息

Adv Drug Deliv Rev. 2010 Feb 17;62(2):246-57. doi: 10.1016/j.addr.2009.12.007. Epub 2010 Jan 7.

DOI:10.1016/j.addr.2009.12.007

PMID:20060431

Abstract

N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers and their drug conjugates are some of the most intensively investigated drug delivery systems for over 30years. Some of the HPMA copolymer drug conjugates have entered clinical trials. Various molecular imaging technologies have been used to investigate the mechanism of drug delivery with HPMA copolymers. Fluorescence imaging has been used for the study of the process of intracellular drug delivery, including cell binding, subcellular trafficking and intracellular fate, of HPMA copolymers and drug conjugates. Magnetic resonance imaging and nuclear medicine, including gamma-scintigraphy, SPECT and PET, have been used for the non-invasive visualization of pharmacokinetics, biodistribution and drug targeting efficiency of HPMA copolymers in animal models. gamma-Scintigraphy has been used to study HPMA copolymer drug conjugates in human patients. The application of imaging technologies in the study of HPMA copolymers and properties of the copolymers demonstrated by imaging is summarized in this review.

摘要

N-(2-羟丙基)甲基丙烯酰胺（HPMA）共聚物及其药物偶联物是 30 多年来研究最深入的药物递送系统之一。一些 HPMA 共聚物药物偶联物已进入临床试验。各种分子成像技术已被用于研究 HPMA 共聚物的药物递送机制。荧光成像已被用于研究 HPMA 共聚物和药物偶联物的细胞内药物递送过程，包括细胞结合、亚细胞转运和细胞内命运。磁共振成像和核医学，包括γ闪烁成像、SPECT 和 PET，已被用于非侵入性可视化 HPMA 共聚物在动物模型中的药代动力学、生物分布和药物靶向效率。γ闪烁成像已被用于研究 HPMA 共聚物药物偶联物在人类患者中的应用。本综述总结了成像技术在 HPMA 共聚物研究中的应用以及通过成像显示的共聚物的特性。