Yang Jiyuan, Kopeček Jindřich
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City 84112, USA.
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City 84112, USA; Department of Bioengineering, University of Utah, Salt Lake City 84112, USA.
J Control Release. 2014 Sep 28;190:288-303. doi: 10.1016/j.jconrel.2014.04.013. Epub 2014 Apr 18.
This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated.
本综述涵盖了水溶性聚合物-药物缀合物以及不连接低分子量药物但具有生物活性的大分子。讨论了传统的和主链可降解的聚合物-药物缀合物的主要设计原则，以及纳米医学新范式——（低分子量）无药物大分子疗法的发展。为了应对癌症的生物学特征，还探讨了针对干细胞/祖细胞和肿瘤微环境的大分子疗法。最后，简要讨论了该领域的未来前景。
