Department of Medicine, University of Toronto, The Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.
Mol Cell Endocrinol. 2010 Sep 15;326(1-2):66-70. doi: 10.1016/j.mce.2009.12.028. Epub 2010 Jan 7.
Pituitary tumorigenesis infrequently involves intragenic mutations of oncogenes or tumor suppressor genes (Asa and Ezzat, 1998, 2002). Increasing evidence suggests that signals implicated in pituitary development may be relevant to neoplastic changes. Equally as important, accumulating evidence suggests that in contrast to other forms of solid neoplasia, pituitary tumors are frequently associated with epigenetic changes. In this review we discuss evolving models of epigenetic control and use members of the fibroblast growth factor receptor (FGF) receptor family as examples of dysregulated signals in pituitary tumorigenesis (Asa and Ezzat, 2009).
垂体肿瘤的发生很少涉及癌基因或肿瘤抑制基因的基因内突变（Asa 和 Ezzat，1998 年，2002 年）。越来越多的证据表明，涉及垂体发育的信号可能与肿瘤的变化有关。同样重要的是，越来越多的证据表明，与其他形式的实体瘤不同，垂体肿瘤常与表观遗传变化有关。在这篇综述中，我们讨论了表观遗传控制的进化模型，并以成纤维细胞生长因子受体（FGF）受体家族成员为例，讨论了它们在垂体肿瘤发生中的失调信号（Asa 和 Ezzat，2009 年）。
