蛋白质的大构象变化：信号转导及其他功能。
Large conformational changes in proteins: signaling and other functions.
机构信息
Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, CA, USA.
出版信息
Curr Opin Struct Biol. 2010 Apr;20(2):142-7. doi: 10.1016/j.sbi.2009.12.004. Epub 2010 Jan 8.
Abstract
Guanine and adenine nucleotide triphosphatases, such as Ras proteins and protein kinases, undergo large conformational changes upon ligand binding in the course of their functions. New computer simulation methods have combined with experimental studies to deepen our understanding of these phenomena. In particular, a 'conformational selection' picture is emerging, where alterations in the relative populations of pre-existing conformations can best describe the conformational switching activity of these important proteins.
摘要
鸟嘌呤和腺嘌呤核苷酸三磷酸酶，如 Ras 蛋白和蛋白激酶，在其功能过程中，当配体结合时会发生大的构象变化。新的计算机模拟方法与实验研究相结合，加深了我们对这些现象的理解。特别是，一种“构象选择”的观点正在出现，其中预先存在的构象的相对种群的改变可以最好地描述这些重要蛋白质的构象转换活性。
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