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Large conformational changes in proteins: signaling and other functions.
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The allosteric switch and conformational states in Ras GTPase affected by small molecules.
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Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.
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A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein.
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Regulators and effectors of ras proteins.
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p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.
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The interaction of Ras with GTPase-activating proteins.
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本文引用的文献

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Ras classical effectors: new tales from in silico complexes.
Trends Biochem Sci. 2009 Nov;34(11):533-9. doi: 10.1016/j.tibs.2009.07.001. Epub 2009 Oct 2.
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Mechanical signaling on the single protein level studied using steered molecular dynamics.
Cell Biochem Biophys. 2009;55(3):141-52. doi: 10.1007/s12013-009-9064-5. Epub 2009 Aug 11.
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Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.
J Struct Biol. 2009 Aug;167(2):117-28. doi: 10.1016/j.jsb.2009.04.007. Epub 2009 May 3.
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Long-timescale molecular dynamics simulations of protein structure and function.
Curr Opin Struct Biol. 2009 Apr;19(2):120-7. doi: 10.1016/j.sbi.2009.03.004. Epub 2009 Apr 8.
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Molecular dynamics simulations of membrane channels and transporters.
Curr Opin Struct Biol. 2009 Apr;19(2):128-37. doi: 10.1016/j.sbi.2009.02.011. Epub 2009 Apr 1.
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Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics.
PLoS Comput Biol. 2009 Mar;5(3):e1000325. doi: 10.1371/journal.pcbi.1000325. Epub 2009 Mar 20.
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Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations.
Cancer Res. 2009 Mar 15;69(6):2384-92. doi: 10.1158/0008-5472.CAN-08-3953. Epub 2009 Mar 10.

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