Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Exp Gerontol. 2010 Apr;45(4):255-68. doi: 10.1016/j.exger.2009.12.013. Epub 2010 Jan 10.
In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.
在这篇综述中，我们描述了正常衰老如何随着时间的推移而积累表观遗传错误，类似于随着年龄增长而积累遗传突变。我们描述了目前如何进行这些实验，以及它们在技术和分析上的局限性及其在衰老研究中的应用。
