衰老过程中表观基因组失调的实验研究方法。
Experimental approaches to the study of epigenomic dysregulation in ageing.
机构信息
Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Exp Gerontol. 2010 Apr;45(4):255-68. doi: 10.1016/j.exger.2009.12.013. Epub 2010 Jan 10.
Abstract
In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.
摘要
在这篇综述中，我们描述了正常衰老如何随着时间的推移而积累表观遗传错误，类似于随着年龄增长而积累遗传突变。我们描述了目前如何进行这些实验，以及它们在技术和分析上的局限性及其在衰老研究中的应用。
相似文献
1
Experimental approaches to the study of epigenomic dysregulation in ageing.衰老过程中表观基因组失调的实验研究方法。
Exp Gerontol. 2010 Apr;45(4):255-68. doi: 10.1016/j.exger.2009.12.013. Epub 2010 Jan 10.
2
DNA methylation and histone variants in aging and cancer.DNA 甲基化和组蛋白变体在衰老和癌症中的作用。
Int Rev Cell Mol Biol. 2021;364:1-110. doi: 10.1016/bs.ircmb.2021.06.002. Epub 2021 Jul 12.
3
Epigenomics and the regulation of aging.表观基因组学与衰老调控。
Epigenomics. 2013 Apr;5(2):205-27. doi: 10.2217/epi.13.5.
4
DNA methylation dynamics in aging: how far are we from understanding the mechanisms?衰老过程中的 DNA 甲基化动态：我们距离理解机制还有多远？
Mech Ageing Dev. 2018 Sep;174:3-17. doi: 10.1016/j.mad.2017.12.002. Epub 2017 Dec 18.
5
Epigenetic analysis in the search for tumor suppressor genes.寻找肿瘤抑制基因中的表观遗传学分析
Epigenomics. 2010 Aug;2(4):489-93. doi: 10.2217/epi.10.29.
6
Aberrant DNA methylation in skin diseases.皮肤疾病中的异常DNA甲基化。
J Dermatol Sci. 2009 Jun;54(3):143-9. doi: 10.1016/j.jdermsci.2009.01.009. Epub 2009 Apr 22.
7
Epigenetic vulnerability and the environmental influence on health.表观遗传脆弱性与环境对健康的影响。
Exp Biol Med (Maywood). 2013 Aug 1;238(8):859-65. doi: 10.1177/1535370213490630. Epub 2013 Jul 4.
8
Childhood intelligence attenuates the association between biological ageing and health outcomes in later life.儿童智力会减弱生物衰老与晚年健康结果之间的关联。
Transl Psychiatry. 2019 Nov 28;9(1):323. doi: 10.1038/s41398-019-0657-5.
9
DNA methylation-based biomarkers and the epigenetic clock theory of ageing.基于 DNA 甲基化的生物标志物和衰老的表观遗传时钟理论。
Nat Rev Genet. 2018 Jun;19(6):371-384. doi: 10.1038/s41576-018-0004-3.
10
Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis?精神分裂症的表观基因组能否为发病机制的分子基础提供线索？
Epigenomics. 2011 Dec;3(6):679-83. doi: 10.2217/epi.11.94.
引用本文的文献
1
Microphysiological systems for human aging research.用于人类衰老研究的微生理系统。
Aging Cell. 2024 Mar;23(3):e14070. doi: 10.1111/acel.14070. Epub 2024 Jan 5.
2
Kidney and epigenetic mechanisms of salt-sensitive hypertension.盐敏感性高血压的肾脏和表观遗传机制。
Nat Rev Nephrol. 2021 May;17(5):350-363. doi: 10.1038/s41581-021-00399-2. Epub 2021 Feb 24.
3
DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.苏格兰一代和 1921 年和 1936 年洛锡安出生队列的 DNA 甲基化异常负担、健康和衰老。
Clin Epigenetics. 2020 Mar 26;12(1):49. doi: 10.1186/s13148-020-00838-0.
4
DNA methylation aging clocks: challenges and recommendations.DNA 甲基化衰老钟：挑战与建议。
Genome Biol. 2019 Nov 25;20(1):249. doi: 10.1186/s13059-019-1824-y.
5
Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake.赖氨酸特异性去甲基化酶-1改变年龄对血压对膳食盐摄入敏感性的影响。
Age (Dordr). 2013 Oct;35(5):1809-20. doi: 10.1007/s11357-012-9480-0. Epub 2012 Oct 2.
6
Molecular marks for epigenetic identification of developmental and cancer stem cells.用于发育和肿瘤干细胞表观遗传学鉴定的分子标记物。
Clin Epigenetics. 2011 Apr;2(1):27-53. doi: 10.1007/s13148-010-0016-0. Epub 2010 Dec 17.
本文引用的文献
1
The role of epigenetics in aging and age-related diseases.表观遗传学在衰老及与年龄相关疾病中的作用。
Ageing Res Rev. 2009 Oct;8(4):268-76. doi: 10.1016/j.arr.2009.03.004. Epub 2009 Apr 1.
2
Aging-associated alteration of subtelomeric methylation in Parkinson's disease.帕金森病中与衰老相关的亚端粒甲基化改变。
J Gerontol A Biol Sci Med Sci. 2009 Sep;64(9):949-55. doi: 10.1093/gerona/glp070. Epub 2009 Jun 5.
3
DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.DNMT3B与组成型着丝粒蛋白CENP-C相互作用，以调节着丝粒区域的DNA甲基化和组蛋白编码。
Hum Mol Genet. 2009 Sep 1;18(17):3178-93. doi: 10.1093/hmg/ddp256. Epub 2009 May 29.
4
Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning.p16INK4A CpG岛的异常从头甲基化在基因沉默后启动，与染色质重塑相关，并模拟核小体定位。
Hum Mol Genet. 2009 Aug 15;18(16):3098-109. doi: 10.1093/hmg/ddp251. Epub 2009 May 28.
5
CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.CXXC 指蛋白 1 包含冗余的功能结构域，这些结构域支持胚胎干细胞的胞嘧啶甲基化、组蛋白甲基化及分化。
Mol Cell Biol. 2009 Jul;29(14):3817-31. doi: 10.1128/MCB.00243-09. Epub 2009 May 11.
6
DNA Methyltransferase protein synthesis is reduced in CXXC finger protein 1-deficient embryonic stem cells.在CXXC指蛋白1缺陷的胚胎干细胞中，DNA甲基转移酶的蛋白质合成减少。
DNA Cell Biol. 2009 May;28(5):223-31. doi: 10.1089/dna.2009.0854.
7
Hunting for the 5th base: Techniques for analyzing DNA methylation.探寻第五种碱基：DNA甲基化分析技术
Biochim Biophys Acta. 2009 Sep;1790(9):847-62. doi: 10.1016/j.bbagen.2009.02.001. Epub 2009 Feb 9.
8
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.靶向和全基因组规模策略揭示人类细胞中的基因体甲基化特征。
Nat Biotechnol. 2009 Apr;27(4):361-8. doi: 10.1038/nbt.1533. Epub 2009 Mar 29.
9
The long and the short of it: RNA-directed chromatin asymmetry in mammalian X-chromosome inactivation.简而言之：哺乳动物X染色体失活中的RNA导向染色质不对称性。
FEBS Lett. 2009 Mar 4;583(5):857-64. doi: 10.1016/j.febslet.2009.02.004. Epub 2009 Feb 8.
10
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.通过SET7介导的赖氨酸甲基化调控哺乳动物细胞中DNMT1的稳定性
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5076-81. doi: 10.1073/pnas.0810362106. Epub 2009 Mar 12.
Zotero 插件