Department of Medicine, University of California, Irvine, CA 92697, USA.
Hum Exp Toxicol. 2010 Jan;29(1):11-4. doi: 10.1177/0960327109354660.
Toxicity Testing in the 21st Century: A Vision and a Strategy (NRC, 2007) presents a bold plan for chemical toxicity testing that replaces whole-animal tests with cell-culture, genetic, other in-vitro techniques, computational methods, and human monitoring. Although the proposed vision is eloquently described, and recent advances in in-vitro and in-silico methods are impressive, it is difficult believe that replacing in-vitro testing is either practical or wise. It is not clear that the toxicity-related events that occur in whole animals can be adequately replicated using the proposed methods. Protecting public health is a serious endeavor that should not be limited by denying animal testing. Toxicologists and regulators are encouraged to read the report, carefully consider its implications, and share their thoughts. The vision is for too important to ignore.
《21 世纪的毒理学测试：展望与策略》（NRC，2007）提出了一项大胆的化学毒理学测试计划，用细胞培养、基因、其他体外技术、计算方法和人体监测取代整体动物测试。尽管所提出的设想描述得很有说服力，而且最近在体外和计算方法方面的进展令人印象深刻，但很难相信用体外测试取代整体动物测试在实践上是可行的，或者是明智的。目前还不清楚使用所提议的方法是否可以充分复制在整体动物中发生的与毒性相关的事件。保护公众健康是一项严肃的努力，不应因拒绝动物测试而受到限制。鼓励毒理学家和监管机构阅读该报告，仔细考虑其影响，并分享他们的想法。这个设想非常重要，不容忽视。
