Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA.
Hum Exp Toxicol. 2010 Jan;29(1):15-9. doi: 10.1177/0960327109354657.
Toxicity Testing in the 21st Century: A Vision and a Strategy, from the National Research Council Committee on Toxicity Testing and Assessment of Environmental Agents, presents a vision wherein toxicology testing moves from feeding test substances to animals for their lifetimes, and assessing clinical laboratory and histopathological changes, to human tissue studies made suitable by recent technological advances in computational biology, toxicogenomics, and the like. This is to be accomplished by elucidating toxicity pathways complemented by targeted testing. The report focuses on the array of available new concepts and attendant technology that the committee considers relevant to its proffer, but, in the final analysis, it describes little in the way of robust strategy for achieving the stated goals. From that perspective, the vision, as described, is no more innovative or far-reaching than goals directed at the utility of cellular metabolism measurements put forth fifty years ago. The report generally lacks the coherence and organization that could have given greater credibility to the committee's deliberative effort.
《21 世纪的毒性测试：愿景与战略》是美国国家研究理事会环境毒物测试与评估委员会提交的报告，提出了一个愿景，即毒性测试将从给动物喂食测试物质并观察其一生，以及评估临床实验室和组织病理学变化，转变为利用计算生物学、毒理学基因组学等方面的最新技术，对人类组织进行研究。这将通过阐明毒性途径并辅以靶向测试来实现。该报告重点介绍了委员会认为与其建议相关的一系列现有新概念和相关技术，但最终并没有提出实现既定目标的具体策略。从这个角度来看，所描述的愿景与 50 年前提出的细胞代谢测量的实用性目标一样，没有更多的创新性或深远性。该报告通常缺乏连贯性和组织性，这可能会降低委员会审议工作的可信度。
