Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Hum Exp Toxicol. 2010 Jan;29(1):31-2. doi: 10.1177/0960327109354662.
The report of the National Academy of Sciences entitled 'Toxicity Testing in the 21st Century: A Vision and a Strategy,' hereinafter referred to as 'The Report,' is more of a vision than of a strategy. The present article addresses three observations made on The Report; namely, dose response, PBPK modeling, and in vitro testing. An additional observation this author has of the document is that a role for a scientist who can analyze the big picture is missing from the document. Science today is necessarily composed of specialists in many areas because science today encompasses many diverse, specific fields. Each specialist is in a world of his or her own and unable to integrate all the facts. Must we wait for another Newton or Einstein?
美国国家科学院题为《21 世纪的毒理学测试：愿景与战略》的报告（以下简称“报告”）与其说是一项战略，不如说是一个愿景。本文针对报告中的三个观察结果进行了讨论：剂量反应、基于生理的药代动力学模型和体外测试。作者对该文件的另一个看法是，该文件缺少能够分析大局的科学家的角色。今天的科学必然由许多领域的专家组成，因为今天的科学包含许多不同的、具体的领域。每个专家都在自己的世界里，无法整合所有的事实。我们是否必须等待另一个牛顿或爱因斯坦？
