Bouyahia Olfa, Khelifi Ibtissem, Gharsallah Lamia, Harzallah Kais, Mrad Sonia Mazigh, Ghargah Tahar, Boukthir Samir, Azza Sammoud El Gharbi
Pediatric's Department, Children's Hospital of Tunis, Tunisia.
Saudi J Kidney Dis Transpl. 2010 Jan;21(1):135-7.
Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebro-spinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he developed severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He remained free of proteinuria during his 20 months of follow-up.
在成人和儿科文献中，仅有少数肾病综合征与吉兰 - 巴雷综合征（GBS）相关的病例报道。一名3岁男孩最初因四肢进行性无力、疲劳、右腿疼痛和麻木5天后入住我院。既往无肾脏或神经系统疾病史。脑脊液检查显示蛋白水平为92mg/dL，每高倍视野白细胞计数为1个。通过神经传导速度测试等证实了GBS的诊断。静脉注射免疫球蛋白后，GBS症状逐渐改善。三周后，他出现了严重蛋白尿和水肿；实验室检查显示为肾病综合征，对类固醇治疗有反应。肾活检显示为微小病变性肾小球肾炎。在20个月的随访期间，他一直没有蛋白尿。
