Department of Family Medicine, Baskent University Faculty of Medicine, Ankara, Turkey.
J Endocrinol Invest. 2010 Jul-Aug;33(7):461-4. doi: 10.1007/BF03346625. Epub 2009 Dec 22.
A recent study showed first sign of reduction in goiter prevalence and elimination of iodine deficiency state among school-age children in Turkey after a decade of mandatory iodination of table salt. However, iodine status among pregnant women is a still debated issue in our country.
To investigate iodine status, iodized salt consumption rate, and goiter prevalence in 1st trimester pregnant women 8 yr after the mandatory iodination. MATERIAL/ SUBJECTS AND METHODS: One hundred and forty-one 1sttrimester pregnant women who had been followed-up between January and October 2006 in the obstetric outpatient clinics in Turkey were included. Besides a physical examination, subjects underwent laboratory investigations for free T(3), free T(4), and urinary iodine concentration (UIC). All subjects completed a questionnaire regarding sociodemographic parameters, use of iodized salt, and pregnancy history. Goiter status was revealed by a palpation method according to World Health Organization (WHO) guidelines.
In this study, we found that the median UIC of pregnant women was 149.7 microg/l (range 20.9-275.1 microg/l). Almost half of the subjects were below the WHO, United Nations Children's Fund, and International Council for the Control of Iodine Deficiency Disorders lower median reference limits of 150 microg/l. Total goiter prevalence was 24.8%, of which 9.2% were visible goiters. Among the study patients, 2.1% had subclinical hypothyroidism, and 0.7% had overt hypothyroidism. The rate for iodized salt use among the pregnant women was 95%.
Our study revealed that iodine deficiency still remains a serious problem for pregnant women. Based on our results, antenatal follow-up protocols in the primary care setting in Turkey must include iodine supplementation.
最近的一项研究表明,在土耳其强制食盐碘化十年后,学龄儿童的甲状腺肿患病率首次出现下降,碘缺乏状态得到消除。然而,孕妇的碘状况在我国仍是一个有争议的问题。
调查强制食盐碘化 8 年后孕妇的碘状况、碘盐食用率和甲状腺肿患病率。
材料/受试者和方法:本研究纳入了 2006 年 1 月至 10 月期间在土耳其妇产科门诊接受随访的 141 名孕早期妇女。除了体格检查外,受试者还进行了游离 T3、游离 T4 和尿碘浓度(UIC)的实验室检查。所有受试者均完成了一份关于社会人口学参数、碘盐使用情况和妊娠史的问卷。甲状腺肿状况根据世界卫生组织(WHO)指南通过触诊法确定。
本研究发现,孕妇的 UIC 中位数为 149.7μg/l(范围 20.9-275.1μg/l)。近一半的受试者低于 WHO、联合国儿童基金会和国际碘缺乏控制理事会的下限参考值 150μg/l。总甲状腺肿患病率为 24.8%,其中 9.2%为可见甲状腺肿。在研究患者中,2.1%患有亚临床甲状腺功能减退症,0.7%患有显性甲状腺功能减退症。孕妇碘盐使用率为 95%。
本研究表明,碘缺乏仍然是孕妇面临的一个严重问题。基于我们的结果,土耳其初级保健机构的产前随访方案必须包括碘补充。