Ucuzian Areck A, Gassman Andrew A, East Andrea T, Greisler Howard P
Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA.
J Burn Care Res. 2010 Jan-Feb;31(1):158-75. doi: 10.1097/BCR.0b013e3181c7ed82.
Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a key component in numerous physiologic and pathologic responses and has broad impact in many medical and surgical specialties. In this review, we discuss the key cellular steps that lead to the neovascularization of tissues and highlight the main molecular mechanisms and mediators in this process. We include discussions on proteolytic enzymes, cell-matrix interactions, and pertinent cell signaling pathways and end with a survey of the mechanisms that lead to the stabilization and maturation of neovasculatures.
血管生成,即从已有的脉管系统形成新的血管,是众多生理和病理反应的关键组成部分,在许多医学和外科专业领域都有广泛影响。在本综述中,我们讨论了导致组织新血管形成的关键细胞步骤,并强调了这一过程中的主要分子机制和介质。我们包括对蛋白水解酶、细胞-基质相互作用以及相关细胞信号通路的讨论,并以对导致新血管稳定和成熟的机制的综述作为结尾。